Importance of Solid L ipid Nanoparticles in Cancer Therapy

A BST R A C T A drug delivery system can be defined as a system that capable of releasing a carried bioactive agents in a specific location within the body at a specific rate. Anticancer drugs can be associated with colloidal carrier systems such as polymeric micelles, nanocapsules, liposomes and solid lipid nanoparticles, which can be actively targeted to specific tumor cell. The treatment of cancer is based on the delivery method. The cancer patients are using various anticancer drugs but these are less effective and have major side effects. Solid lipid nanoparticles (SLNs) have been introduced as an alternative drug carrier system to drug delivery. Due to the disadvantages of the other colloidal carriers (liposomes, emulsions, and polymeric microand nanoparticles), SLN developed. In this study, we determined how SLN can be used for cancer therapy. As a result, substances which have anti-cancer properties loaded SLN formulations were significantly more effective than free substances on cancer therapy. K eywords: Drug Delivery Systems, SLNs, Cancer Therapy.